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The synthesized nanogels were based on dextran which was cross-linked with disulfide containing moiety (cystamine) for conferring sensitivity towards GSH

Xu W, Ding J, Xiao C, Li L, Zhuang X, Chen X

Some metabolic enzymes, such as succinate dehydrogenase (SDH), fumarate hydratase (FH), IDH and pyruvate kinase 2 (PKM2) are likely to activate HIF-1 pathway by stabilizing HIF-1, therefore enhancing cancer metastasis (258)